A novel biomarker of laminin turnover is associated with mortality and disease progression in chronic kidney disease
Abstract
INTRODUCTION AND AIMS: Patients with chronic kidney disease (CKD) have increased risk of progressing to end-stage renal disease (ESRD) and a high mortality rate. One of the major underlying causes of progression of renal failure is renal fibrosis, which is caused by dysregulated extracellular matrix (ECM) remodeling. The laminin γ1 (LAMC1) chain is a constituent of the laminin types present in the glomerular basement membrane (GBM), and its turnover may be altered in CKD. Fragments of LAMC1 could quantify GBM turnover in human CKD and reflect pathological tissue changes. We developed an immunoassay targeting LG1M, a neo-epitope of LAMC1 generated by matrix metalloproteinases (MMPs). We then measured LG1M levels in serum and urine from a large prospective cohort of patients with high-risk CKD.
Info
Conference Abstract, 2017
UN SDG Classification
DK Main Research Area
Science/Technology
