Abstract
Wound healing is a dynamic process characterized by three overlapping cellular phases: inflammation, new tissue formation, and remodeling. Chronic wounds, which are often manifested in elderly and diabetic patients, result from anomalies in the cellular and molecular wound repair mechanism. Such wounds can lead to significant disability, amputation and increased mortality. The understanding of the normal wound healing mechanism and the consideration of the complexity of the wound environment, given by, e.g., hypoxia or bacterial infections, are crucial factors in order to develop an effective therapeutic approach. Systemic drug delivery systems, such as oral and intravenous delivery, are the most common routes for drug administration. Nevertheless, these routes are characterized by several significant drawbacks. For instance, systemic delivery requires an appropriate blood perfusion of the target tissue, often insufficient in chronic wounds, and carries with it a high risk for systemic toxicity, which can limit dosing and duration of the medical treatment. Therefore, localized drug delivery is a promising approach to improve bioavailability and maintenance of a therapeutic drug concentration, while minimizing systemic drug toxicity. Here, we propose a novel, skin-friendly, industrially relevant silicone/glycerol hybrid adhesive with new functional properties, including: improved moisture handling due to the incorporation of emulsified glycerol and dispersion of an antimicrobial agent by glycerol-embedding. This particular matrix paves the way for an innovative drug delivery system. Various parameters will be taken into account in order to develop a relevant adhesive, in particular glycerol content, glycerol domain size and adhesive thickness.
Info
Conference Abstract, 2018
UN SDG Classification
DK Main Research Area
Science/Technology
