Abstract
Intestinal infectious diseases remain a serious problem for the health care. In many countries, especially in Armenia, the most common intestinal infection is salmonellosis, which is caused by various serotypes of Salmonella. It is the most common causative agent of food-borne diseases. Although the members of the Salmonella genus are genetically close, they display wide variations in host-specificity, virulence, and disease manifestations. Gastroenteritis is most frequently caused by Salmonella enterica serovar Typhimurium (S. Typhimurium) and Salmonella enteric serovar Enteritidis (S.Enteritidis). Previously, we reported that the induction of the cytokine network and an antimicrobial protein is serotype-specific and also depends on the disease stage. Differential genomic context of the serotypes may explain the differential induction of inflammatory responses. Recent studies have indicated that bacterial infections in early life may help to inhibit excessive allergic Th2 reactions by angling the immune system towards Th1 responses. However, it is known that infections can also cause the exacerbation of allergic reactions. Skewing of response away from Treg cells may lead to the onset and/or progression of autoimmune diseases in humans. It is also thought that there is a high probability that infectious gastroenteritis increases the risk of subsequent autoimmune and allergic diseases.
Info
Conference Abstract, 2013
UN SDG Classification
DK Main Research Area
Science/Technology
