Screening of Aspergillus nidulans metabolites from habitat mimicking media using LC-DAD-TOFMS system
Abstract
Fungi are a valuable source of metabolites and other bioactive compounds. These compounds are essential for human society, and it is estimated that around 49% of the drugs used to treat cancer are natural products or derived therefrom. Six different wild types of Aspergillus nidulans have been cultured on a range of different habitat mimicking media. Extracts from the fungi were analyzed using a LC-DAD-TOFMS system, and by screening the extracts using an in-house database of known fungal metabolites. Using this database we were able to easily select unknown compounds, and dereplicate these using the spectrometric and spectroscopic data obtained from the analysis. The Analysis revealed several metabolites not previously reported in A. nidulans as well as a novel metabolite.
Info
Conference Abstract, 2012
UN SDG Classification
DK Main Research Area
Science/Technology
