Research
Simple estimate of the influence of competitive inhibition on PBTK based risk assessment
Abstract
Background: In recent years, increased focus has been on the development of methods for assessing health risks caused by exposure to mixtures of chemicals from food and the environment. It has been recommended by international bodies to consider physiologically based toxicokinetic (PBTK) modelling for higher tier cumulative risk assessment of chemicals. Another important area for the use of PBTK is risk assessment of aggregate exposure via different routes (dietary, dermal, etc.).