Single-Shot-RARE for rapid 3D hyperpolarized metabolic ex vivo tissue imaging: RF-pulse design for semi-dense spectra
Abstract
MRS of hyperpolarized (HP) 13C-enriched compounds is a promising method for in vivo cancer diagnosis . Sentinel lymph node ex vivo tissue sample histology used in clinical routine for breast cancer metastasis diagnosis requires time consuming sample analysis. 3D-HP-MRSI can potentially speed up the diagnosis given a sensitive marker that can be efficiently imaged in tissue after homogenous injection. The entire sample can be confined within the imaged volume giving the possibility of complete spatial non-selectivity of the radio frequency (RF) pulses in the RF pulse design with no chemical shift localization errors. Since only a few product signals are of interest for this application, a combination of under-sampled temporal encoding, frequency selective excitation and the Single-Shot-RAREsequence offers favourable SNR characteristics. Small peak separations are challenging, however, since they require narrow excitation transition-bands. We have designed a 3D-MRSI pulse sequence for hyperpolarized ex vivo sample imaging for semi-dense compound spectra (few components, relatively small separations), ultimately aimed to be used for metastasis detection in excised lymph nodes.
Info
Conference Poster, 2016
UN SDG Classification
DK Main Research Area
Science/Technology
