Upregulation of TGF-beta 1 in neonates of mothers receiving Influenza A (H1N1) vaccination during pregnancy
Abstract
Background: Influenza vaccination of pregnant women is generally considered safe,but the effects on the immune system of the unborn child are unknown.Objectives: Our primary objective was to explore differences in cytokine and chemokine levels in nasal mucosal lining fluid in neonates of mothers vaccinated during or after pregnancy. Method: IFN-c, IL-1b, IL-2, -4, -5, -10, - 12p70, -13, -17, TNF-a, IL-8, eotaxin-1,eotaxin-3, IP-10, MCP-1, MCP-4, MDC, MIP-1b, TGF-b1 and TARC were quantified in nasal mucosal lining fluid in neonates of mothers receiving Influenza A (H1N1v) vaccine during (n = 52) or after pregnancy (n = 118) in our unselected Copenhagen Prospective Study on Asthma in Childhood 2010 birth-cohort. Result: Neonates of mothers vaccinated during pregnancy showed a significant up-regulation of the immune-regulatory TGF-b1 (P = 0.0004), significant down regulation (P < 0.05) of TARC, IL-5, )8, )10, )12p70, eotaxin-1, MDC, IFN-c and non-significant down regulation of nearly all other mediators except for MCP-4,IL-17, eotaxin-3 compared to neonates of mothers vaccinated after pregnancy.Results are adjusted for season; airway colonization S. pneumoniae, H. influenzae, M.catarrhalis, and S. aureus; older siblings; furred animals in home; smoking during 3rd trimester; and mothers’ atopic disease. Conclusion: These findings suggest that Influenza A (H1N1) vaccination during pregnancy affects the mucosal immune competence of the unborn child. The up-regulation of TGF-b1 and down-regulation of nearly all essential contributors to protective immunity reflect an imprinting suggestive of immune inhibition that may affect the neonates’ ability to combat respiratory tract infections.
Info
Conference Abstract, 2012
UN SDG Classification
DK Main Research Area
Science/Technology
